Présentation

Singh S et al.
Genomic alterations driving psoriasis pathogenesis.
Gene. 2019 Jan 30, 683:61-71.

Psoriasis is an immune mediated inflammatory skin disease with complex etiology involving interplay between environmental and genetic risk factors as disease initiating event. Enhanced understanding on genetic risk factors, differentially expressed genes, deregulated proteins and pathway-targeted therapeutics have established multiple axis of psoriasis pathogenesis. So far, loci in 424 genes are reported to be associated with psoriasis alongside copy number variations and epigenetic (...)

Panahi Y et al.
Evidence of curcumin and curcumin analogue effects in skin diseases: A narrative review.
J. Cell. Physiol.. 2019 Feb , 234, (2):1165-1178.

Curcumin, a natural polyphenolic and yellow pigment obtained from the spice turmeric, has strong antioxidative, anti-inflammatory, and antibacterial properties. Due to these properties, curcumin has been used as a remedy for the prevention and treatment of skin aging and disorders such as psoriasis, infection, acne, skin inflammation, and skin cancer. Curcumin has protective effects against skin damage caused by chronic ultraviolet B radiation. One of the challenges in maximizing the (...)

Tian Z et al.
A Chinese cross-sectional study on depression and anxiety symptoms in patients with psoriasis vulgaris.
Psychol Health Med. 2019 Mar , 24, (3):269-280.

Previous studies have reported a higher incidence of depression and anxiety in psoriasis patients compared to the general population, which has important implications for assessment and treatment. In this study, we determined the frequency of depression and anxiety in Chinese patients with psoriasis and its relationship with disease severity and other demographic variables. The study included 208 Chinese patients with psoriasis vulgaris. The Patient Health Questionnaire (PHQ-9) and (...)

Kusari A et al.
Atopic Dermatitis: New Developments.
Dermatol Clin. 2019 Jan , 37, (1):11-20.

Herein we review recent developments in our understanding and treatment of atopic dermatitis. Key insights from the recent literature are summarized, from findings on the pathogenesis of this multifactorial disease to a new and more nuanced understanding of its natural history. Therapeutic advances and new data on comorbidities are also discussed.

Qureshi A et al.
Comorbidities in Dermatology: What's Real and What's Not.
Dermatol Clin. 2019 Jan , 37, (1):65-71.

Comorbidities affecting dermatologic patients are of significant importance to providers and highly relevant for appropriate patient counseling, screening practices, prevention, and treatment. This article seeks to highlight several of the newest findings in the literature regarding comorbidities associated with dermatologic diseases including atopic dermatitis, hidradenitis suppurativa, alopecia areata, chronic urticaria, and the pemphigus family of immunobullous diseases. Further (...)

Tham EH et al.
Mechanisms by Which Atopic Dermatitis Predisposes to Food Allergy and the Atopic March.
Allergy Asthma Immunol Res. 2019 Jan , 11, (1):4-15.

The Atopic march denotes the progression from atopic dermatitis (AD) to the development of other allergic disorders such as immunoglobulin (Ig) E-mediated food allergy, allergic rhinitis and asthma in later childhood. There is increasing evidence from prospective birth cohort studies that early-onset AD is a risk factor for other allergic diseases or is found in strong association with them. Animal studies now provide mechanistic insights into the pathways that may be responsible for (...)